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pentobarbital will decrease the extent or influence of amlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.Contraindicated (1)pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can lower panobinostat concentrations by ~70